Based on new geographic economics,this study uses the panel data of 31 provinces in China from 2009 to 2020,and empirically analyzes the impact of higher education agglomeration on economic growth and spatial spillover effect through spatial Dobbin model. The research finds that both higher education agglomeration and economic development in China show the distribution character- istics of gradually weakening from east to west; Higher education agglomeration has a significant positive impact on the regional eco- nomic growth,and the spatial spillover effect is significant; The interaction with human capital is not significant; The interaction with R & D has a significant positive impact on the regional economic growth,but the spatial spillover effect is not significant; Human cap- ital and scientific and technological R & D play a significant role in the joint regulation between higher education agglomeration and e- conomic growth,and the spatial spillover effect is significant. Therefore,we should not only improve the quality of higher education in China and attach importance to the development of higher education in the central and western regions,but also focus on talent train- ing,introduction,scientific and technological research and development,achieve the effective combination of human capital and scien- tific and technological research and development,and give play to the economic growth effect of higher education.