Discipline is a kind of organizational logic of knowledge system and the carrier of university. Constructing first - class disciplines is a powerful way to materialize the function of universities,the development of teachers and students,the optimization of academic ecologyand the excellence of universities. It is of great significance to the high - quality development of China’s economy and society,the great rejuvenation of the Chinese nation,and consolidate the cultural confidence. Compared with affiliated universities and eastern local universities,local universities in central and western regions are facing a more severe situation in the construction of first - class disciplines,such as low attraction of first - class talents,limited construction funds,lagging discipline development mecha- nism,decision - making limited to short - term interests,and outstanding imbalance of academic ecosystem. First - class local universi- ty construction in central and western China must be based on the basic law of first - class discipline construction,adhere to the“first - class standard”,“people - oriented”,“differentiation”,“relative advantages”,“benefit and fairness”,“system guarantee”, “learning innovation”and“gradual implementation”principles,combining with regional demand and actual school,explore suitable for their own road. The following strategies can be adopted: multiple difference construction objectives,pay attention to the construction of first - class management system and teaching and research team construction,optimize the academic ecosystem,vigorously explore diversified funding channels,reasonably balance the development needs of various disciplines,and adhere to innovation in the disci- pline construction.