In order to improve the effectiveness of college’s entrepreneurship education,we must pay attention to the integration and development of craftsmanship spirit from the perspective of“cultivating morality and cultivating talents”. Entrepreneurship educa- tion in colleges should match and integrate craftsmanship spirit based on market economy and the law of education development,so as to present the connotation of innovation and practice in science and technology dimension,pursuit of excellence in quality dimension, focus on cooperation and sharing in team dimension,dare to take responsibility in risk dimension,and pay attention to inheritance and development in teacher - student dimension. Colleges and universities should construct the materialized mechanism of craftsmanship spirit in entrepreneurship education in terms of market mechanism,quality mechanism,teacher - student community mechanism and entrepreneurship training mechanism,so as to promote the connotative development of entrepreneurship education in colleges and uni- versities from the aspects of formulating incentive policies,running through the process of excellence,building a new relationship be- tween teachers and apprentices,and creating the character of innovative talents with both morality and art.