Under the background of the current“human - computer interaction”autonomous learning model,proper guidance of arning strategies is an effective way to improve college students’English vocabulary acquisition. The author adopts the vocabulary test nd the vocabulary strategy questionnaire to explore the correlation between learning strategies and college students’vocabulary quantity autonomous learning. Research shows that there is a significant correlation between students’vocabulary learning strategies and their ocabulary quantity. The application level of college students’vocabulary learning strategies is positively correlated with their English ocabulary acquisition. This paper proposes a variety of ways to construct a new model of English vocabulary autonomous learning,ho- ing to provide an all - round guidance to college students,enhancing their self - confidence and cultivating the ability of continuous elf - learning.